Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Clinics in Geriatric MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Epidemiology and unique aspects of aging and infectious diseases.Clin Infect Dis. 2000; 30: 931-933
- Respiratory impairment and the aging lung: a novel paradigm for assessing pulmonary function.J Gerontol A Biol Sci Med Sci. 2012; 67: 264-275
- Cellular signaling in the aging immune system.Curr Opin Immunol. 2014; 29: 105-111
- Age-dependent dysregulation of innate immunity.Nat Rev Immunol. 2013; 13: 875-887
- A high plasma concentration of TNF-alpha is associated with dementia in centenarians.J Gerontol A Biol Sci Med Sci. 1999; 54: M357-M364
- Increased cytokine production in mononuclear cells of healthy elderly people.Eur J Immunol. 1993; 23: 2375-2378
- Hypercoagulability in centenarians: the paradox of successful aging.Blood. 1995; 85: 3144-3149
- Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha.Am J Physiol. 1998; 275: E294-E299
- Plasma cytokine levels in a population-based study: relation to age and ethnicity.J Gerontol A Biol Sci Med Sci. 2010; 65: 429-433
- Increase of plasma IL-6 concentration with age in healthy subjects.Life Sci. 1992; 51: 1953-1956
- Elevated levels of tumor necrosis factor alpha and mortality in centenarians.Am J Med. 2003; 115: 278-283
- Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly.Am J Med. 1999; 106: 506-512
- Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons.J Am Geriatr Soc. 2002; 50: 638-644
- Inflamm-aging does not simply reflect increases in pro-inflammatory markers.Mech Ageing Dev. 2014; 139: 49-57
- Inflamm-aging. An evolutionary perspective on immunosenescence.Ann N Y Acad Sci. 2000; 908: 244-254
- Immune system, cell senescence, aging and longevity–inflamm-aging reappraised.Curr Pharm Des. 2013; 19: 1675-1679
- Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies.Life Sci. 1989; 44: 1655-1664
- Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence.Blood. 2014; 123: 239-248
- Effect of age on human neutrophil function.J Leukoc Biol. 2000; 67: 40-45
- Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans.J Leukoc Biol. 2001; 70: 881-886
- Aging reduces the functionality of anti-pneumococcal antibodies and the killing of streptococcus pneumoniae by neutrophil phagocytosis.Vaccine. 2011; 29: 1929-1934
- Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.Aging Cell. 2014; 13: 690-698
- GM-CSF activates the JAK/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals.Biogerontology. 2007; 8: 173-187
- Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.J Leukoc Biol. 2006; 79: 1061-1072
- Reduced bioenergetics and Toll-like receptor 1 function in human polymorphonuclear leukocytes in aging.Aging (Albany NY). 2014; 6: 131-139
- Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary inflammation.Aging Dis. 2012; 3: 234-247
- The three human monocyte subsets: implications for health and disease.Immunol Res. 2012; 53: 41-57
- Impaired functions of peripheral blood monocyte subpopulations in aged humans.J Clin Immunol. 2010; 30: 806-813
- Age-associated defect in human TLR-1/2 function.J Immunol. 2007; 178: 970-975
- Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults.J Infect Dis. 2007; 195: 1590-1597
- Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly.Aging Cell. 2012; 11: 104-110
- Flagellin-dependent TLR5/Caveolin-1 as a promising immune activator in immunosenescence.Aging Cell. 2015; 14: 907-915
- Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.Aging Cell. 2012; 11: 867-875
- Senescent CD14+CD16+ monocytes exhibit proinflammatory and proatherosclerotic activity.J Immunol. 2011; 186: 1809-1815
- Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults.BMC Immunol. 2010; 11: 30
- Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.J Infect Dis. 2015; 211: 1174-1184
- Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without weight loss in older adults.Eur J Appl Physiol. 2014; 114: 1737-1748
- Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?.J Leukoc Biol. 2008; 84: 1271-1278
- Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.J Immunol. 2010; 184: 2518-2527
- Impaired secretion of interferons by dendritic cells from aged subjects to influenza: role of histone modifications.Age (Dordr). 2013; 35: 1785-1797
- Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus.J Infect Dis. 2011; 203: 1415-1424
- Alterations in gene array patterns in dendritic cells from aged humans.PLoS One. 2014; 9: e106471
- Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway.J Immunol. 2007; 178: 6912-6922
- Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA.J Immunol. 2009; 182: 1138-1145
- Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.Mucosal Immunol. 2014; 7: 1386-1394
- Innate lymphoid cells–a proposal for uniform nomenclature.Nat Rev Immunol. 2013; 13: 145-149
- Proinflammatory status influences NK cells subsets in the elderly.Immunol Lett. 2014; 162: 298-302
- Effect of age and CMV on NK cell subpopulations.Exp Gerontol. 2014; 54: 130-137
- NK phenotypic markers and IL2 response in NK cells from elderly people.Exp Gerontol. 1999; 34: 253-265
- Ageing is associated with a decline in peripheral blood CD56bright NK cells.Immun Ageing. 2006; 3: 10
- Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset.Hum Immunol. 2010; 71: 676-681
- Human NK cells display major phenotypic and functional changes over the life span.Aging Cell. 2010; 9: 527-535
- Shaping of NK cell subsets by aging.Curr Opin Immunol. 2014; 29: 56-61
- Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans.Semin Immunol. 2012; 24: 331-341
- Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity.Aging Cell. 2012; 11: 751-759
- Association between natural killer cell activity and infection in immunologically normal elderly people.Clin Exp Immunol. 2001; 124: 392-397
- Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.J Immunol. 2009; 183: 1393-1402
- Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men.J Clin Endocrinol Metab. 2006; 91: 345-347
- Dehydroepiandrosterone as a regulator of immune cell function.J Steroid Biochem Mol Biol. 2010; 120: 127-136
- Gene expression markers of age-related inflammation in two human cohorts.Exp Gerontol. 2015; 70: 37-45
- Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue.J Immunol. 2011; 187: 6208-6216
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.Proc Natl Acad Sci U S A. 2015; 112: E6301-E6310
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.J Clin Invest. 2013; 123: 966-972
- mTOR is a key modulator of ageing and age-related disease.Nature. 2013; 493: 338-345
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.Nat Cell Biol. 2015; 17: 1205-1217
- mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1a translation.Nat Cell Biol. 2015; 17: 1049-1061
- Late-life rapamycin treatment reverses age-related heart dysfunction.Aging Cell. 2013; 12: 851-862
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.Nature. 2009; 460: 392-395
- mTOr signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia.J Immunol. 2014; 192: 6009-6019
- mTOR inhibition improves immune function in the elderly.Sci Transl Med. 2014; 6: 268ra179
- Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the vitality 90+ study.Exp Gerontol. 2012; 47: 372-378
- Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the vitality 90+ study.Mech Ageing Dev. 2011; 132: 20-26
- Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty.Aging Cell. 2013; 12: 388-397
- Mitochondrial DNA released by trauma induces neutrophil extracellular traps.PLoS One. 2015; 10: e0120549
- Circulating mitochondrial DNA increases with age and is a familiar trait: implications for “inflamm-aging”.Eur J Immunol. 2014; 44: 1552-1562
- Mitochondrial DAMPS induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction.PLoS One. 2014; 9: e95073
- Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.Immunity. 2012; 36: 401-414
- Initiation and perpetuation of nlrp3 inflammasome activation and assembly.Immunol Rev. 2015; 265: 35-52
- Acetaminophen-induced hepatotoxicity in mice is dependent on TLR9 and the NALP3 inflammasome.J Clin Invest. 2009; 119: 305-314
- Necrotic cells trigger a sterile inflammatory response through the NLRP3 inflammasome.Proc Natl Acad Sci U S A. 2009; 106: 20388-20393
- Cutting edge: necrosis activates the NLRP3 inflammasome.J Immunol. 2009; 183: 1528-1532
- Canonical NLRP3 inflammasome links systemic low-grade inflammation to functional decline in aging.Cell Metab. 2013; 18: 519-532
- The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.Nat Immunol. 2014; 15: 738-748
- The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.Nat Immunol. 2014; 15: 727-737
- The effect of age on thymic function.Front Immunol. 2013; 4: 316
- Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.Immunity. 2012; 36: 288-297
- Evidence of premature immune aging in patients thymectomized during early childhood.J Clin Invest. 2009; 119: 3070-3078
- Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals.Clin Exp Immunol. 2009; 155: 423-432
- Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets.Immun Ageing. 2011; 8: 2
- Role of cytomegalovirus in the T cell changes seen in elderly individuals.Clin Immunol. 1999; 90: 213-219
- Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor g1 (KLRG1).Exp Gerontol. 2003; 38: 911-920
- Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study.Exp Gerontol. 2002; 37: 445-453
- Cytomegalovirus reactivation in critically ill immunocompetent patients.JAMA. 2008; 300: 413-422
- Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.J Immunol. 2014; 192: 2143-2155
- Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.J Immunol. 2006; 176: 2645-2653
- Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.J Immunol. 2002; 169: 1984-1992
- Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old.J Clin Immunol. 2003; 23: 247-257
- Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly.Exp Gerontol. 2004; 39: 607-613
- Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status.J Immunol. 2010; 184: 3242-3249
- Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling.J Immunol. 2014; 192: 2689-2698
- Diversity and clonal selection in the human T-cell repertoire.Proc Natl Acad Sci U S A. 2014; 111: 13139-13144
- Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach.Phil Trans R Soc B. 2015; 370: 20140291
- CD28(-) T cells: their role in the age-associated decline of immune function.Trends Immunol. 2009; 30: 306-312
- Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production.J Exp Med. 2003; 198: 947-955
- T cell replicative senescence in human aging.Curr Pharm Des. 2013; 19: 1680-1698
- Increased T-Bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.J Leukoc Biol. 2013; 93: 825-836
- KLRG1–more than a marker for T cell senescence.Age (Dordr). 2009; 31: 285-291
- Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity.Nat Med. 2012; 18: 1518-1524
- Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age.Proc Natl Acad Sci U S A. 2012; 109: E879-E888
- P38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells.J Clin Invest. 2014; 124: 4004-4016
- The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.Nat Immunol. 2014; 15: 965-972
- B-cell diversity decreases in old age and is correlated with poor health status.Aging Cell. 2009; 8: 18-25
- Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.J Immunol. 2014; 192: 603-611
- Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue.Scand J Immunol. 2006; 64: 314-324
- Ageing of the B-cell repertoire.Phil Trans R Soc B. 2015; 370: 20140237
- Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies.J Clin Invest. 2011; 121: 3109-3119
- Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans.Vaccine. 2010; 28: 8077-8084
- Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells.J Immunol. 2008; 180: 5283-5290
- MicroRNAs miR-155 and miR-16 decrease AID and E47 in B cells from elderly individuals.J Immunol. 2015; 195: 2134-2140
- High TNF-alpha levels in resting B cells negatively correlate with their response.Exp Gerontol. 2014; 54: 116-122
- Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine.Vaccine. 2015; 33: 1433-1439
- Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.Aging Cell. 2015; 14: 421-432
- Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.Aging (Albany NY). 2015; 7: 38-52
- Apoptosis and other immune biomarkers predict influenza vaccine responsiveness.Mol Syst Biol. 2013; 9: 659
- Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.Crit Care. 2015; 19: 77
- Aging and DNA methylation.BMC Biol. 2015; 13: 7
- DNA methylation age of blood predicts all-cause mortality in later life.Genome Biol. 2015; 16: 25
- The microbiota and microbiome in aging: potential implications in health and age-related diseases.J Am Geriatr Soc. 2015; 63: 776-781
Article info
Publication history
Published online: May 25, 2016
Footnotes
The authors’ work was supported by the National Institutes of Health (HHS N272201100019C, U19 AI089992, K24 AG042489, and T32 AI007517) and was carried out in collaboration with the Yale Claude D. Pepper Older Americans Independence Center (P30AG21342). The authors regret being unable to include many important articles due to space and scope limitations.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
