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References
- Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.Circulation. 2007; 115: e69-e171
- Prevalence of overweight and obesity in the United States, 1999–2004.JAMA. 2006; 295: 1549-1555
- Heart disease and stroke statistics—2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.Circulation. 2008; 117: e25-e146
- Deaths: preliminary data for 2004.Natl Vital Stat Rep. 2006; 54: 1-49
- Childhood obesity—the shape of things to come.N Engl J Med. 2007; 357: 2325-2327
- Obesity and the heart: a weighty issue.J Am Coll Cardiol. 2006; 47: 2274-2276
- Report of the second world assembly on aging.United Nations, Madrid (Spain)2002
- International database. Table 094. Midyear population, by age and sex.(Available at:) (Accessed June 24, 2009)
- The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.JAMA. 2003; 289: 2560-2572
- Obesity in the pediatric patient: cardiovascular complications.Prog Pediatr Cardiol. 2001; 12: 161-167
- Assessment of cardiac autonomic modulation during adolescent obesity.Obes Res. 2003; 11: 541-548
- Clinical and epidemiological significance of left ventricular mass assessed in children and adolescents.Circulation. 1998; 97: 1893-1894
- Myocardial velocity, strain, and strain rate abnormalities in healthy obese children.J Cardiometab Syndr. 2007; 2: 30-34
Barrett J. The price of childhood obesity: why the costs could catastrophic if we don’t stop the epidemic now. Newsweek. Accessed December 5, 2007.
- Pediatric obesity: an overview of etiology and treatment.Pediatr Clin North Am. 1997; 44: 339-361
- Impact of obesity on cardiac geometry and function in a population of adolescents: the strong heart study.J Am Col Cardiol. 2006; 47 ([commentary]): 2267-2276
- Increased left ventricular mass in obese adolescents.Eur Heart J. 2004; 25: 987-992
- Determination of left ventricular mass by echocardiography in a normal population: effect of age and sex in addition to body size.Mayo Clin Proc. 1994; 69: 205-211
- Echocardiography-based left ventricular mass estimation. How should we define hypertrophy?.Cardiovasc Ultrasound. 2005; 3: 17
- Value of body fat mass vs anthropometric obesity indices in the assessment of metabolic risk factors.Int J Obes (Lond). 2006; 30: 475-483
- Obesity and the heart: redefinition of the relationship.Obes Rev. 2007; 8: 35-39
- Alterations of left ventricular myocardial characteristics associated with obesity.Circulation. 2004; 110: 3081-3087
- Central fat mass versus peripheral fat and lean mass: opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study.J Clin Endocrinol Metab. 2004; 89: 2632-2639
- The metabolic syndrome.Lancet. 2005; 365: 1415-1428
- Banting lecture 1988. Role of insulin resistance in human disease; 1988.Nutrition. 1997; 13 ([discussion: 64, 66]): 65
- The IDF consensus worldwide definition of the metabolic syndrome.(Available at:) (Accessed June 24, 2009)
- Definition, diagnosis, and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation.Diabet Med. 1998; 15: 539-553
- Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR).Diabet Med. 1999; 16: 442-443
- American College of Endocrinology position statement on the insulin resistance syndrome.Endocr Pract. 2003; 9: 237-252
- Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition.Arterioscler Thromb Vasc Biol. 2004; 24: e13-e18
- Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.Circulation. 2005; 112: 2735-2752
- Metabolic syndrome, or what you will: definitions and epidemiology.Diab Vasc Dis Res. 2007; 4: 32-38
- Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies.J Am Coll Cardiol. 2007; 49: 403-414
- The metabolic syndrome: beyond the insulin resistance syndrome.Pharmacol Res. 2006; 53: 457-468
- The metabolic syndrome and inflammation.Metab Syndr Relat Disord. 2004; 2: 82-104
- A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?.Diabetes. 2005; 54: 917-927
- Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone.Diabetes. 2005; 54: 2305-2313
- Obesity is associated with macrophage accumulation in adipose tissue.J Clin Invest. 2003; 112: 1796-1808
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.J Clin Invest. 2003; 112: 1821-1830
- Metabolic syndrome and C-reactive protein among cardiology patients.Arch Med Res. 2007; 38: 783-788
- Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).Circulation. 2000; 102: 42-47
- Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis.Arterioscler Thromb Vasc Biol. 2007; 27: 2276-2283
- C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14,719 initially healthy American women.Circulation. 2003; 107: 391-397
- C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study.Circulation. 2004; 110: 380-385
- Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people.J Am Coll Cardiol. 2007; 49: 1798-1805
- Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study.Diabet Care. 2002; 25: 2016-2021
- C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men.Diabetologia. 2004; 47: 1403-1410
- Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome: role of tumor necrosis factor-alpha.Nutr Metab Cardiovasc Dis. 2007; 17: 274-279
- Dietary restriction: current status.Aging. 2001; 13: 261-262
- Overview of caloric restriction and ageing.Mech Ageing Dev. 2005; 126: 913-922
- The retardation of aging and disease by dietary restriction.Charles C. Thomas, Springfield (IL)1988
- How diet influences the aging process of the rat.Proc Soc Exp Biol Med. 2004; 205: 97-105
- Effects of diet restriction on life span and age-related changes in dogs.J Am Vet Med Assoc. 2002; 220: 1315-1320
- Diet restriction and ageing in the dog: major observations over two decades.Br J Nutr. 2008; 99: 793-805
- Nonhuman primates: essential partners in biomedical research.Immunol Rev. 2001; 183: 5-9
- Primates.Science. 1988; 240: 1475-1482
- DNA hybridization evidence of hominoid phylogeny: results from an expanded data set.J Mol Evol. 1987; 26: 99-121
- DNA hybridization evidence of hominoid phylogeny: a reanalysis of the data.J Mol Evol. 1990; 30: 202-236
- Skeletal aging in macaque monkeys.in: Erwin J.M. Hof P.R. Aging in nonhuman primates. Interdisciplinary topics in gerontology. Karger, Basel (Switzerland)2002: 32-47
- Aging experiments in nonhuman primates.in: Yu B.P. Methods in aging research. CRC Press, Boca Raton (FL)1998: 249-267
- The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys.Horm Metab Res. 2003; 35: 617-624
- Changes in lipoprotein concentrations during the development of noninsulin-dependent diabetes mellitus in obese rhesus monkeys (Macaca mulatta).J Clin Endocrinol Metab. 1991; 72: 1067-1072
- Heterogeneity of insulin responses: phases leading to type 2 (noninsulin-dependent) diabetes mellitus in the rhesus monkey.Diabetologia. 1986; 29: 713-719
- Effects of gender and social behavior on the development of coronary artery atherosclerosis in cynomolgus macaques.Atherosclerosis. 1983; 48: 221-233
- Deleterious effects of hypertension on the development of aortic and coronary atherosclerosis in stumptail macaques (Macaca speciosa) on an atherogenic diet.Circ Res. 1974; 35: 472-482
- Atherosclerosis in rhesus monkeys. II. Arterial lesions associated with hypercholesteremia induced by dietary fat and cholesterol.Arch Pathol. 1962; 74: 16-34
- Caloric restriction in primates.Ann N Y Acad Sci. 2001; 928: 287-295
- Dietary restriction in aging nonhuman primates.Interdiscip Top Gerontol. 2007; 35: 137-158
- Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study.J Gerontol. 1993; 48: B17-B26
- Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study.Exp Gerontol. 2000; 35: 1131-1149
- Mortality and morbidity in laboratory-maintained rhesus monkeys and effects of long-term dietary restriction.J Gerontol. 2003; 58: 212-219
- A study of caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): a potential model for aging research.J Gerontol A Biol Sci Med Sci. 1997; 52: B10-B19
- Body fat distribution with long-term dietary restriction in adult male rhesus macaques.J Gerontol Biol Sci. 1999; 54A: B283-B290
- Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial.J Gerontol A Biol Sci Med Sci. 2004; 59: 1007-1014
- Dietary restriction and beta-cell sensitivity to glucose in adult male rhesus monkeys.J Gerontol A Biol Sci Med Sci. 2003; 58: 598-610
- Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr.Am J Physiol Endocrinol Metab. 2001; 281: E757-E765
- Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys.Am J Physiol. 1994; 266: E540-E547
- Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points.Am J Physiol. 1995; 268: E941-E948
- Long-term dietary restriction in older-aged rhesus monkeys: effects on insulin resistance.J Gerontol A Biol Sci Med Sci. 1995; 50: B142-B147
- Influence of caloric restriction on the development of atherosclerosis in nonhuman primates: progress to date.Toxicol Sci. 1999; 52: 49-55
- Primary prevention of diabetes mellitus by prevention of obesity in monkeys.Diabetes. 1993; 42: 1809-1814
- Calorie restriction in nonhuman primates: implications for age-related disease risk.J Antiaging Med. 1998; 1: 315-326
- Caloric restriction in rhesus monkeys reduces low-density lipoprotein interaction with arterial proteoglycans.J Gerontol A Biol Sci Med Sci. 1998; 53: B443-B448
- Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys.Exp Gerontol. 2001; 36: 1413-1418
- Caloric restriction increases HDL2 levels in rhesus monkeys (Macaca mulatta).Am J Physiol. 1997; 273: E714-E719
- Caloric restriction delays disease onset and mortality in rhesus monkeys.Science. 2009; 325: 201-204
- Epidemiologic data on the relationships of caloric intake, energy balance, and weight gain over the life span with longevity and morbidity.J Gerontol. 2001; 56: 7-19
- Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging.N Engl J Med. 1997; 337: 986-994
- The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans.Proc Natl Acad Sci U S A. 1992; 89: 11533-11537
- Physiologic changes in humans subjected to severe, selective calorie restriction for two years in Biosphere 2: health, aging, and toxicological perspectives.Toxicol Sci. 1999; 52: 61-65
- Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period.J Gerontol A Biol Sci Med Sci. 2002; 57: B211-B224
- Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.Proc Natl Acad Sci U S A. 2004; 101: 6659-6663
- One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue.J Gerontol A Biol Sci Med Sci. 2006; 61: 943-950
- Effect of calorie restriction with or without exercise on body composition and fat distribution.J Clin Endocrinol Metab. 2007; 92: 865-872
- Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial.Am J Physiol Endocrinol Metab. 2007; 293: E197-E202
- Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.JAMA. 2006; 295: 1539-1548
- Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects.Diabetes Care. 2006; 29: 1337-1344
- Caloric restriction alone and with exercise improves CVD risk in healthy nonobese individuals.Atherosclerosis. 2009; 203: 206-213
- Dietary restriction in nonhuman primates: progress report on the NIA study.Ann N Y Acad Sci. 1992; 673: 36-45
- Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk.Toxicol Sci. 1999; 52: 41-48
- The effect of dietary restriction on body composition in adult male and female rhesus macaques.Aging (Milano). 1998; 10: 83-92
- Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2.Arch Intern Med. 1998; 158: 900-906
- Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates.Exp Gerontol. 2009; 44: 356-362
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Footnotes
This work was supported by grants P01 AG-11915 (National Institute on Aging) and P51 RR000167 (National Center for Research Resources [NCRR]). This research was conducted in part at a facility constructed with support from Research Facilities Improvement Program grant numbers RR15459-01 and RR020141-01 from NCRR.
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