Keywords
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Clinics in Geriatric MedicineReferences
- Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.Lancet. 1997; 349: 1436-1442
- Shattuck lecture—cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities.N Engl J Med. 1997; 337: 1360-1369
- Coronary risk factors in the elderly: their interactions and treatment.Curr Pharm Des. 2003; 9: 2465-2478
- Cardiovascular risk factors in the elderly.Coron Artery Dis. 1997; 8: 565-575
- Molecular inflammation: underpinnings of aging and age-related diseases.Ageing Res Rev. 2009; 8: 18-30
- Confirmation of a heart failure epidemic: findings from the Resource Utilization Among Congestive Heart Failure (REACH) study.J Am Coll Cardiol. 2002; 39: 60-69
- Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults.J Am Geriatr Soc. 1997; 45: 968-974
- Evidence of improving prognosis in heart failure: trends in case fatality in 66547 patients hospitalized between 1986 and 1995.Circulation. 2000; 102: 1126-1131
- The retardation of aging and disease by dietary restriction.Charles C Thomas Publisher, Springfield (IL)1988
- Caloric restriction in humans: potential pitfalls and health concerns.Mech Ageing Dev. 2006; 127: 1-7
- The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake.J Nutr. 1986; 116: 641-654
- The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats.Toxicol Pathol. 2000; 28: 285-296
- Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.Proc Natl Acad Sci U S A. 2004; 101: 6659-6663
- Long-term caloric restriction ameliorates the decline in diastolic function in humans.J Am Coll Cardiol. 2006; 47: 398-402
- Aging: a theory based on free radical and radiation chemistry.J Gerontol. 1956; 11: 298-300
- The biologic clock: the mitochondria?.J Am Geriatr Soc. 1972; 20: 145-147
- Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis.Ann N Y Acad Sci. 1996; 786: 1-11
- A proposed refinement of the mitochondrial free radical theory of aging.Bioessays. 1997; 19: 161-166
- The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis.Eur J Biochem. 2002; 269: 1996-2002
- Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse.Mech Ageing Dev. 1994; 74: 121-133
- Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice.Mech Ageing Dev. 1994; 76: 215-224
- Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.Arch Biochem Biophys. 1997; 346: 74-80
- Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2'-deoxyguanosine in organs of Fischer 344 rats during aging.Free Radic Biol Med. 1997; 23: 76-81
- Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals.FASEB J. 2000; 14: 312-318
- Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging.FASEB J. 2005; 19: 419-421
- Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts.Biochem Biophys Res Commun. 1992; 189: 979-985
- Evidence for the role of oxidative stress in acute ischemic heart disease: a brief review.Can J Cardiol. 1999; 15: 587-593
- Role of oxidative stress in cardiac remodelling after myocardial infarction.Heart Lung Circ. 2004; 13: 132-138
- Oxidative stress and redox signalling in cardiac hypertrophy and heart failure.Heart. 2007; 93: 903-907
- Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation.Aging Cell. 2009; 8: 226-238
- Endothelial function and oxidative stress.Endothelium. 2004; 11: 123-132
- Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart.FASEB J. 2001; 15: 1589-1591
- Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.Free Radic Res. 2002; 36: 47-54
- Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.Mech Ageing Dev. 2002; 123: 1437-1446
- Dietary restriction and fibre supplementation: oxidative stress and metabolic shifting for cardiac health.Can J Physiol Pharmacol. 2003; 81: 1042-1048
- Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage.Cardiovasc Res. 2007; 74: 456-465
- Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart.Am J Physiol Regul Integr Comp Physiol. 2003; 284: R474-R480
- Effects of aging and anti-aging caloric restrictions on carbonyl and heat shock protein levels and expression.Biogerontology. 2005; 6: 397-406
- Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle.J Biol Chem. 1977; 252: 8731-8739
- Structure of cristae in cardiac mitochondria of aged rat.Mech Ageing Dev. 2006; 127: 917-921
- Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart.Am J Physiol Regul Integr Comp Physiol. 2005; 289: R1564-R1572
- Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.J Gerontol A Biol Sci Med Sci. 2006; 61: 211-217
- Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium.Circ Res. 1999; 85: 357-363
- Activation of NADPH oxidase during progression of cardiac hypertrophy to failure.Hypertension. 2002; 40: 477-484
- Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy.Circ Res. 2006; 98: 271-279
- Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.J Card Fail. 2008; 14: 746-753
- Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers.Circulation. 2003; 107: 416-421
- Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats.Can J Physiol Pharmacol. 2007; 85: 1236-1247
- Moderate calorie restriction improves cardiac remodeling and diastolic dysfunction in the Dahl-SS rat.J Mol Cell Cardiol. 2006; 41: 661-668
- Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury.Am J Physiol Heart Circ Physiol. 2001; 280: H2094-H2102
- Calorie restriction improves cardiovascular risk factors via reduction of mitochondrial reactive oxygen species in type II diabetic rats.J Pharmacol Exp Ther. 2007; 320: 535-543
- Weight loss in combination with physical activity improves endothelial dysfunction in human obesity.Diabetes Care. 2003; 26: 1673-1678
- Atherosclerosis—an inflammatory disease.N Engl J Med. 1999; 340: 115-126
- The molecular inflammatory process in aging.Antioxid Redox Signal. 2006; 8: 572-581
- Up-and-coming markers: myeloperoxidase, a novel biomarker test for heart failure and acute coronary syndrome application?.Congest Heart Fail. 2008; 14: 46-48
- Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells.Circulation. 2002; 106: 1439-1441
- The role of tumor necrosis factor in cardiac disease.Heart Dis. 2001; 3: 319-325
- Interleukin-6 and cardiovascular diseases.Jpn Heart J. 2004; 45: 183-193
- Adhesion molecules and atherosclerosis.Atherosclerosis. 2003; 170: 191-203
- Cytokine regulation of cellular adhesion molecule expression in inflammation.Cytokine Growth Factor Rev. 1999; 10: 27-39
- Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction.FASEB J. 2004; 18: 320-322
- Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction.FASEB J. 2005; 19: 668-670
- Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats.J Gerontol A Biol Sci Med Sci. 2007; 62: 1082-1087
- Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction.Free Radic Res. 2005; 39: 283-289
- Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta).J Nutr. 1995; 125: 1600-1610
- Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones.J Clin Endocrinol Metab. 2006; 91: 3232-3235
- Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3.J Clin Endocrinol Metab. 2008; 93: 3226-3229
- Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.Am J Clin Nutr. 2004; 79: 544-551
- Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.Br J Cancer. 1972; 26: 239-257
- The role of apoptosis in the normal aging brain, skeletal muscle, and heart.Ann N Y Acad Sci. 2002; 959: 93-107
- Age-related death-survival balance in myocardium: an immunohistochemical and biochemical study.Mech Ageing Dev. 2002; 123: 341-350
- Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart.FASEB J. 2006; 20: 791-793
- Myocardial aging and senescence: where have the stem cells gone?.Annu Rev Physiol. 2004; 66: 29-48
- Reperfusion injury induces apoptosis in rabbit cardiomyocytes.J Clin Invest. 1994; 94: 1621-1628
- Apoptosis in myocytes in end-stage heart failure.N Engl J Med. 1996; 335: 1182-1189
- Myocardial cell death in human diabetes.Circ Res. 2000; 87: 1123-1132
- Apoptosis and related proteins in different stages of human atherosclerotic plaques.Circulation. 1998; 97: 2307-2315
- Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts.Proc Natl Acad Sci U S A. 2002; 99: 14988-14993
- Caloric restriction and mitochondrial function in the ageing myocardium.Exp Gerontol. 2006; 41: 525-531
- Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: Effects of aging and lifelong calorie restriction.Mech Ageing Dev. 2009; 130: 297-307
- The mitochondrial permeability transition pore and its role in cell death.Biochem J. 1999; 341: 233-249
- Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1.Am J Physiol Heart Circ Physiol. 2008; 295: H2348-H2355
- Cytokines and cardiomyocyte death.Ann Med. 1997; 29: 339-343
- Oxidative stress and apoptosis in heart dysfunction.Herz. 2002; 27: 662-668
- Development by self-digestion: molecular mechanisms and biological functions of autophagy.Dev Cell. 2004; 6: 463-477
- Autophagy in health and disease: a double-edged sword.Science. 2004; 306: 990-995
- Autophagy: many paths to the same end.Mol Cell Biochem. 2004; 263: 55-72
- The molecular mechanism of autophagy.Mol Med. 2003; 9: 65-76
- Oxidative stress, accumulation of biological ‘garbage’, and aging.Antioxid Redox Signal. 2006; 8: 197-204
- The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.Nat Med. 2007; 13: 619-624
- Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.Nature. 2000; 406: 902-906
- On the nature of cell death during remodeling of hypertrophied human myocardium.J Mol Cell Cardiol. 2000; 32: 161-175
- Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms.Circulation. 2003; 107: 984-991
- Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death.J Am Coll Cardiol. 2004; 43: 2191-2199
- Myocytes die by multiple mechanisms in failing human hearts.Circ Res. 2003; 92: 715-724
- Autophagy in chronically ischemic myocardium.Proc Natl Acad Sci U S A. 2005; 102: 13807-13812
- When lysosomes get old.Exp Gerontol. 2000; 35: 119-131
- The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases.Int J Biochem Cell Biol. 2004; 36: 2392-2404
- Autophagy in cardiac myocyte homeostasis, aging, and pathology.Cardiovasc Res. 2005; 68: 355-365
- Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions.J Gerontol A Biol Sci Med Sci. 2001; 56: B375-B383
- Autophagy in the heart and liver during normal aging and calorie restriction.Rejuvenation Res. 2007; 10: 281-292
- Siblings of Okinawan centenarians share lifelong mortality advantages.J Gerontol A Biol Sci Med Sci. 2006; 61: 345-354
- Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians.Prev Med. 1978; 7: 205-217
- Effect of modest weight loss on changes in cardiovascular risk factors: are there differences between men and women or between weight loss and maintenance?.Int J Obes Relat Metab Disord. 1995; 19: 67-73
- Screening and interventions for obesity in adults: summary of the evidence for the U.S. Preventive Services Task Force.Ann Intern Med. 2003; 139: 933-949
- One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue.J Gerontol A Biol Sci Med Sci. 2006; 61: 943-950
- Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial.Am J Physiol Endocrinol Metab. 2007; 293: E197-E202
- Effects of short-term hypocaloric diet on sympatho-vagal interaction assessed by spectral analysis of heart rate and blood pressure variability during stress tests in obese hypertensive patients.Hypertens Res. 2007; 30: 1199-1203
- Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function.J Am Coll Cardiol. 2008; 52: 1006-1012
- Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.Aging Cell. 2008; 7: 681-687
- Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.JAMA. 2006; 295: 1539-1548
- Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.PLoS Med. 2007; 4: e76
- Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals.Atherosclerosis. 2009; 203: 206-213
- Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.Obesity (Silver Spring). 2008; 16: 1355-1362
- Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial.Am J Clin Nutr. 2006; 84: 1033-1042
- Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans.Rejuvenation Res. 2008; 11: 793-799
- Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients.Physiol Res. 2005; 54: 33-39
- The danger of weight loss in the elderly.J Nutr Health Aging. 2008; 12: 487-491
- Body mass index and mortality among older people living in the community.J Am Geriatr Soc. 1999; 47: 1072-1076
- Body mass index and mortality among hospitalized patients.Arch Intern Med. 2000; 160: 2641-2644
- Caloric restriction mimetics: the next phase.Ann N Y Acad Sci. 2005; 1057: 365-371
- 2-Deoxy-d-glucose feeding in rats mimics physiological effects of calorie restriction.J Anti Aging Med. 1998; 1: 327-337
- Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the ‘French paradox’?.Eur J Endocrinol. 1998; 138: 619-620
- Calorie restriction—the SIR2 connection.Cell. 2005; 120: 473-482
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.Nature. 2003; 425: 191-196
- A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.Dev Cell. 2005; 9: 605-615
- Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.Curr Biol. 2006; 16: 296-300
- Opposite effects of two resveratrol (trans-3,5,4′-trihydroxystilbene) tetramers, vitisin A and hopeaphenol, on apoptosis of myocytes isolated from adult rat heart.J Pharmacol Exp Ther. 2009; 328: 90-98
- The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury.Free Radic Biol Med. 1999; 27: 160-169
- Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol.Am J Physiol Heart Circ Physiol. 2007; 292: H2138-H2143
- Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta.Gen Pharmacol. 1996; 27: 363-366
- Antiplatelet activity of synthetic and natural resveratrol in red wine.Int J Tissue React. 1995; 17: 1-3
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.Am J Physiol Heart Circ Physiol. 2008; 294: H2721-H2735
- Resveratrol improves health and survival of mice on a high-calorie diet.Nature. 2006; 444: 337-342
- Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart.Exp Gerontol. 2008; 43: 859-866
- Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease.Eur J Cardiovasc Prev Rehabil. 2005; 12: 596-600
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress.J Nutr. 2005; 135: 1911-1917
Article info
Footnotes
This research was supported by grants to C.L. (NIA R01-AG17994 and AG21042) and C.S.C, (NIH R01-AG024526-02), and the University of Florida Institute on Aging and Claude D. Pepper Older Americans Independence Center (1 P30AG028740).