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Review Article| Volume 25, ISSUE 4, P677-702, November 2009

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Effects of Physical Activity on Cardiovascular and Noncardiovascular Outcomes in Older Adults

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      References

        • Lunney J.R.
        • Lynn J.
        • Foley D.J.
        • et al.
        Patterns of functional decline at the end of life.
        JAMA. 2003; 289: 2387-2392
        • Province M.A.
        • Hadley E.C.
        • Hornbrook M.C.
        • et al.
        The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and injuries: cooperative studies of intervention techniques.
        JAMA. 1995; 273: 1341-1347
        • Rhodes R.E.
        • Martin A.D.
        • Taunton J.E.
        • et al.
        Factors associated with exercise adherence among older adults: an individual perspective.
        Sports Med. 1999; 28: 397-411
        • DiPietro L.
        Physical activity in aging: changes in patterns and their relation to health and function.
        J Gerontol A Biol Sci Med Sci. 2001; 56A: 13-22
        • Lakatta E.G.
        • Levy D.
        Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a “Set Up” for vascular disease.
        Circulation. 2003; 107: 139-146
        • DeSouza C.A.
        • Shapiro L.F.
        • Clevenger C.M.
        • et al.
        Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men.
        Circulation. 2000; 102: 1351-1357
        • Kitzman D.W.
        Diastolic heart failure in the elderly.
        Heart Fail Rev. 2002; 7: 17-27
        • Grewal J.
        • McCully R.B.
        • Kane G.C.
        • et al.
        Left ventricular function and exercise capacity.
        JAMA. 2009; 301: 286-294
        • Xiao R.P.
        • Tomhave E.D.
        • Wang D.J.
        • et al.
        Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
        J Clin Invest. 1998; 101: 1273-1282
        • Kleiger R.E.
        • Stein P.K.
        • Bigger J.T.
        Heart rate variability: measurement and clinical utility.
        Ann Noninvasive Electrocardiol. 2005; 10: 1-14
        • Grimby G.
        • Saltin B.
        The ageing muscle.
        Clin Physiol. 1983; 3: 209-218
        • Visser M.
        • Goodpaster B.H.
        • Kritchevsky S.B.
        • et al.
        Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons.
        J Gerontol A Biol Sci Med Sci. 2005; 60: 324-333
        • Jette A.M.
        • Branch L.G.
        The Framingham disability study: II. Physical disability among the aging.
        Am J Public Health. 1981; 71: 1211-1216
        • Danneskiold-Samsøe B.
        • Kofod V.
        • Munter J.
        • et al.
        Muscle strength and functional capacity in 78–81-year-old men and women.
        Eur J Appl Physiol Occup Physiol. 1984; 52: 310-314
        • Ji L.L.
        Antioxidant signaling in skeletal muscle: a brief review.
        Exp Gerontol. 2007; 42: 582-593
        • Vasan R.S.
        • Sullivan L.M.
        • Roubenoff R.
        • et al.
        Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham heart study.
        Circulation. 2003; 107: 1486-1491
        • Roubenoff R.
        Catabolism of aging: is it an inflammatory process?.
        Curr Opin Clin Nutr Metab Care. 2003; 6: 295-299
        • Brinkley T.E.
        • Leng X.
        • Miller M.E.
        • et al.
        Chronic inflammation is associated with low physical function in older adults across multiple comorbidities.
        J Gerontol A Biol Sci Med Sci. 2009; 64: 455-461
        • Reuben D.B.
        • Cheh A.I.
        • Harris T.B.
        • et al.
        Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons.
        J Am Geriatr Soc. 2002; 50: 638-644
        • Cappola A.R.
        • Xue Q.-L.
        • Ferrucci L.
        • et al.
        Insulin-like growth factor I and Interleukin-6 contribute synergistically to disability and mortality in older women.
        J Clin Endocrinol Metab. 2003; 88: 2019-2025
        • Demissie S.
        • Levy D.
        • Benjamin E.J.
        • et al.
        Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham heart study.
        Aging Cell. 2006; 5: 325-330
        • Festa A.
        • D'Agostino Jr., R.
        • Williams K.
        • et al.
        The relation of body fat mass and distribution to markers of chronic inflammation.
        Int J Obes Relat Metab Disord. 2001; 25: 1407-1415
        • Cesari M.
        • Kritchevsky S.B.
        • Baumgartner R.N.
        • et al.
        Sarcopenia, obesity, and inflammation–results from the trial of angiotensin converting enzyme inhibition and novel cardiovascular risk factors study.
        Am J Clin Nutr. 2005; 82: 428-434
        • Ettinger M.P.
        Aging bone and osteoporosis: strategies for preventing fractures in the elderly.
        Arch Intern Med. 2003; 163: 2237-2246
        • Looker A.C.
        • Orwoll E.S.
        • Johnston C.C.J.
        • et al.
        Prevalence of low femoral bone density in older U.S. adults from NHANES III.
        J Bone Miner Res. 1997; 12: 1761-1768
        • Wark J.D.
        Osteoporosis: the emerging epidemic.
        Med J Aust. 1996; 164: 327-328
        • Fleg J.L.
        • Morrell C.H.
        • Bos A.G.
        • et al.
        Accelerated longitudinal decline of aerobic capacity in healthy older adults.
        Circulation. 2005; 112: 674-682
        • Koopman R.
        • van Loon L.J.C.
        Aging, exercise and muscle protein metabolism.
        J Appl Physiol. 2008; (in press)
      1. Physical Activity Guidelines Advisory Committee, Physical Activity Guidelines Advisory Committee Report, US Department of Health and Human Service. Washington, DC: 2008.

        • Gates P.E.
        • Seals D.R.
        Decline in large elastic artery compliance with age: a therapeutic target for habitual exercise.
        Br J Sports Med. 2006; 40: 897-899
        • Seals D.R.
        • DeSouza C.A.
        • Donato A.J.
        • et al.
        Habitual exercise and arterial aging.
        J Appl Physiol. 2008; 105: 1323-1332
        • Tanabe T.
        • Maeda S.
        • Miyauchi T.
        • et al.
        Exercise training improves ageing-induced decrease in eNOS expression of the aorta.
        Acta Physiol Scand. 2003; 178: 3-10
        • Sugawara J.
        • Otsuki T.
        • Tanabe T.
        • et al.
        Physical activity duration, intensity, and arterial stiffening in postmenopausal womenast.
        Am J Hypertens. 2006; 19: 1032-1036
        • Tanaka H.
        • DeSouza C.A.
        • Seals D.R.
        Absence of age-related increase in central arterial stiffness in physically active women.
        Arterioscler Thromb Vasc Biol. 1998; 18: 127-132
        • Taddei S.
        • Galetta F.
        • Virdis A.
        • et al.
        Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes.
        Circulation. 2000; 101: 2896-2901
        • Hambrecht R.
        • Fiehn E.
        • Weigl C.
        • et al.
        Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure.
        Circulation. 1998; 98: 2709-2715
        • Stratton J.R.
        • Levy W.C.
        • Cerqueira M.D.
        • et al.
        Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men.
        Circulation. 1994; 89: 1648-1655
        • Forman D.E.
        • Manning W.J.
        • Hauser R.
        • et al.
        Enhanced left ventricular diastolic filling associated with long-term endurance training.
        J Gerontol A Biol Sci Med Sci. 1992; 47: M56-M58
        • Leosco D.
        • Rengo G.
        • Iaccarino G.
        • et al.
        Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.
        Am J Physiol Heart Circ Physiol. 2007; 293: H1596-H1603
        • Lahiri M.K.
        • Kannankeril P.J.
        • Goldberger J.J.
        Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications.
        J Am Coll Cardiol. 2008; 51: 1725-1733
        • Plisiene J.
        • Blumberg A.
        • Haager G.
        • et al.
        Moderate physical exercise: a simplified approach for ventricular rate control in older patients with atrial fibrillation.
        Clin Res Cardiol. 2008; 97: 820-826
        • Earnest C.P.
        • Lavie C.J.
        • Blair S.N.
        • et al.
        Heart rate variability characteristics in sedentary postmenopausal women following six months of exercise training: the DREW study.
        PLoS ONE. 2008; 3: e2288
        • Melo R.C.
        • Santos M.D.
        • Silva E.
        • et al.
        Effects of age and physical activity on the autonomic control of heart rate in healthy men.
        Braz J Med Biol Res. 2005; 38: 1331-1338
        • Buchheit M.S.
        • Simon C.
        • Viola A.U.
        • et al.
        Heart rate variability in sportive elderly: relationship with daily physical activity.
        Med Sci Sports Exerc. 2004; 36: 601-605
        • Dietrich D.F.
        • Ackermann-Liebrich U.
        • Schindler C.
        Effect of physical activity on heart rate variability in normal weight, overweight and obese subjects: results from the SAPALDIA study.
        Eur J Appl Physiol. 2008; 104: 557-565
        • Adamo M.L.
        • Farrar R.P.
        Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process.
        Ageing Res Rev. 2006; 5: 310-331
      2. Vale RG, de Oliveira RD, Pernambuco CS, et al. Effects of muscle strength and aerobic training on basal serum levels of IGF-1 and cortisol in elderly women. Arch Gerontol Geriatr 2009, Jan 6. [Epub ahead of print].

        • Abramson J.L.
        • Vaccarino V.
        Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults.
        Arch Intern Med. 2002; 162: 1286-1292
        • Mora S.
        • Lee I.M.
        • Buring J.E.
        • et al.
        Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women.
        JAMA. 2006; 295: 1412-1419
        • Pischon T.
        • Hankinson S.E.
        • Hotamisligil G.S.
        • et al.
        Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers.
        Obes Res. 2003; 11: 1055-1064
        • Ford J.L.
        • Downes S.
        Cellularity of human annulus tissue: an investigation into the cellularity of tissue of different pathologies.
        Histopathology. 2002; 41: 531-537
        • Geffken D.F.
        • Cushman M.
        • Burke G.L.
        • et al.
        Association between physical activity and markers of inflammation in a healthy elderly population.
        Am J Epidemiol. 2001; 153: 242-250
        • Reuben D.B.
        • Judd-Hamilton L.
        • Harris T.B.
        • et al.
        The associations between physical activity and inflammatory markers in high-functioning older persons: macarthur studies of successful aging.
        J Am Geriatr Soc. 2003; 51: 1125-1130
        • Covas M.I.
        • Elosua R.
        • Fito M.
        • et al.
        Relationship between physical activity and oxidative stress biomarkers in women.
        Med Sci Sports Exerc. 2002; 34: 814-819
        • Elosua R.
        • Molina L.
        • Fito M.
        • et al.
        Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women.
        Atherosclerosis. 2003; 167: 327-334
        • Roberts C.K.
        • Won D.
        • Pruthi S.
        • et al.
        Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors.
        J Appl Physiol. 2006; 100: 1657-1665
        • Cherkas L.F.
        • Hunkin J.L.
        • Kato B.S.
        • et al.
        The association between physical activity in leisure time and leukocyte telomere length.
        Arch Intern Med. 2008; 168: 154-158
        • Renehan A.G.
        • Tyson M.
        • Egger M.
        • et al.
        Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
        Lancet. 2008; 371: 569-578
        • Field A.E.
        • Coakley E.H.
        • Must A.
        • et al.
        Impact of overweight on the risk of developing common chronic diseases during a 10-year period.
        Arch Intern Med. 2001; 161: 1581-1586
        • Klein S.
        • Burke L.E.
        • Bray G.A.
        • et al.
        Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association council on nutrition, physical activity, and metabolism: endorsed by the American College of Cardiology Foundation.
        Circulation. 2004; 110: 2952-2967
        • Irwin M.L.
        • Yasui Y.
        • Ulrich C.M.
        • et al.
        Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial.
        JAMA. 2003; 289: 323-330
        • Ross R.
        • Janssen I.
        • Dawson J.
        • et al.
        Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial.
        Obesity Research. 2004; 12: 789-798
        • Olson T.P.
        • Dengel D.R.
        • Leon A.S.
        • et al.
        Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women.
        Int J Obes. 2007; 31: 996-1003
        • Iwamoto J.
        • Takeda T.
        • Ichimura S.
        Effect of exercise training and detraining on bone mineral density in postmenopausal women with osteoporosis.
        J Orthop Sci. 2001; 6: 128-132
        • Gass M.
        • Dawson-Hughes B.
        Preventing osteoporosis-related fractures: an overview.
        Am J Med. 2006; 119: S3-11
        • Todd J.A.
        • Robinson R.J.
        Osteoporosis and exercise.
        Postgrad Med J. 2003; 79: 320-323
        • Cussler E.C.
        • Going S.B.
        • Houtkooper L.B.
        • et al.
        Exercise frequency and calcium intake predict 4-year bone changes in postmenopausal women.
        Osteoporos Int. 2005; 16: 2129-2141
        • Nelson M.E.
        • Fiatarone M.A.
        • Morganti C.M.
        • et al.
        Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial.
        JAMA. 1994; 272: 1909-1914
        • Goldspink D.F.
        • Burniston J.G.
        • Tan L.B.
        Cardiomyocyte death and the ageing and failing heart.
        Exp Physiol. 2003; 88: 447-458
        • Pimentel A.E.
        • Gentile C.L.
        • Tanaka H.
        • et al.
        Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men.
        J Appl Physiol. 2003; 94: 2406-2413
        • Fleg J.L.
        • Pina I.L.
        • Balady G.J.
        • et al.
        Assessment of functional capacity in clinical and research applications: an advisory from the committee on exercise, rehabilitation, and prevention, council on clinical cardiology, American Heart Association.
        Circulation. 2000; 102: 1591-1597
        • Frontera W.R.
        • Meredith C.N.
        • O'Reilly K.P.
        • et al.
        Strength conditioning in older men: skeletal muscle hypertrophy and improved function.
        J Appl Physiol. 1988; 64: 1038-1044
        • Halverstadt A.
        • Phares D.A.
        • Wilund K.R.
        • et al.
        Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women.
        Metabolism. 2007; 56: 444-450
        • Kelley G.A.
        • Kelley K.S.
        Aerobic exercise and resting blood pressure in older adults: a meta-analytic review of randomized controlled trials.
        J Gerontol A Biol Sci Med Sci. 2001; 56: M298-M303
        • O'Rourke M.F.
        • Hashimoto J.
        Mechanical factors in arterial aging: a clinical perspective.
        J Am Coll Cardiol. 2007; 50: 1-13
        • Vaitkevicius P.V.
        • Fleg J.L.
        • Engel J.H.
        • et al.
        Effects of age and aerobic capacity on arterial stiffness in healthy adults.
        Circulation. 1993; 88: 1456-1462
        • Jeon C.Y.
        • Lokken R.P.
        • Hu F.B.
        • et al.
        Physical activity of moderate intensity and risk of type 2 diabetes: a systematic review.
        Diabetes Care. 2007; 30: 744-752
        • Helmrich S.P.
        • Ragland D.R.
        • Leung R.W.
        • et al.
        Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus.
        N Engl J Med. 1991; 325: 147-152
        • Manson J.E.
        • Stampfer M.J.
        • Colditz G.A.
        • et al.
        Physical activity and incidence of non-insulin-dependent diabetes mellitus in women.
        Lancet. 1991; 338: 774-778
        • Hu F.B.
        • Sigal R.J.
        • Rich-Edwards J.W.
        • et al.
        Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study.
        JAMA. 1999; 282: 1433-1439
        • Hu G.
        • Qiao Q.
        • Silventoinen K.
        • et al.
        Occupational, commuting, and leisure-time physical activity in relation to risk for type 2 diabetes in middle-aged Finnish men and women.
        Diabetologia. 2003; 46: 322-329
        • Lynch J.
        • Helmrich S.P.
        • Lakka T.A.
        • et al.
        Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men.
        Arch Intern Med. 1996; 156: 1307-1314
        • Pan X.R.
        • Li G.W.
        • Hu Y.H.
        • et al.
        Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study.
        Diabetes Care. 1997; 20: 537-544
        • Eriksson J.
        • Lindström J.
        • Valle T.
        • et al.
        Prevention of type II diabetes in subjects with impaired glucose tolerance: the diabetes prevention study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme.
        Diabetologia. 1999; 42: 793-801
        • Tuomilehto J.
        • Lindstrom J.
        • Eriksson J.G.
        • et al.
        Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
        N Engl J Med. 2001; 344: 1343-1350
        • Hsia J.
        • Wu L.
        • Allen C.
        • et al.
        Physical activity and diabetes risk in postmenopausal women.
        Am J Prev Med. 2005; 28: 19-25
        • Folsom A.R.
        • Kushi L.H.
        • Ching-Ping H.
        Physical activity and mellitus in postmenopausal women.
        Am J Public Health. 2000; 90: 134-138
        • Schneider S.H.
        • Amorosa L.F.
        • Khachadurian A.K.
        • et al.
        Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes.
        Diabetologia. 1984; 26: 355-360
        • Lanza I.R.
        • Short D.K.
        • Short K.R.
        • et al.
        Endurance exercise as a countermeasure for aging.
        Diabetes. 2008; 57: 2933-2942
        • Snowling N.J.
        • Hopkins W.G.
        Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis.
        Diabetes Care. 2006; 29: 2518-2527
        • DiPietro L.
        • Seeman T.E.
        • Stachenfeld N.S.
        • et al.
        Moderate-intensity aerobic training improves glucose tolerance in aging independent of abdominal adiposity.
        J Am Geriatr Soc. 1998; 46: 875-879
        • Van Dam R.M.
        • Schuit A.J.
        • Feskens E.J.
        • et al.
        Physical activity and glucose tolerance in elderly men: the Zutphen Elderly study.
        Med Sci Sports Exerc. 2002; 34: 1132-1136
        • Hu G.
        • Eriksson J.
        • Barengo N.C.
        • et al.
        Occupational, commuting, and leisure-time physical activity in relation to total and cardiovascular mortality among Finnish subjects with type 2 diabetes.
        Circulation. 2004; 110: 666-673
        • Tanasescu M.
        • Leitzmann M.F.
        • Rimm E.B.
        • et al.
        Physical activity in relation to cardiovascular disease and total mortality among men with type 2 diabetes.
        Circulation. 2003; 107: 2435-2439
        • Hu F.B.
        • Stampfer M.J.
        • Solomon C.
        • et al.
        Physical activity and risk for cardiovascular events in diabetic women.
        Ann Intern Med. 2001; 134: 96-105
        • Balducci S.
        • Iacobellis G.
        • Parisi L.
        • et al.
        Exercise training can modify the natural history of diabetic peripheral neuropathy.
        J Diabetes Complications. 2006; 20: 216-223
        • Sofi F.
        • Capalbo A.
        • Cesari F.
        • et al.
        Physical activity during leisure time and primary prevention of coronary heart disease: an updated meta-analysis of cohort studies.
        Eur J Cardiovasc Prev Rehabil. 2008; 15: 247-257
        • Kohl 3rd, H.W.
        Physical activity and cardiovascular disease: evidence for a dose response.
        Med Sci Sports Exerc. 2001; 33: S472-S483
        • Tanasescu M.
        • Leitzmann M.F.
        • Rimm E.B.
        • et al.
        Exercise type and intensity in relation to coronary heart disease in men.
        JAMA. 2002; 288: 1994-2000
        • Manson J.E.
        • Hu F.B.
        • Rich-Edwards J.W.
        • et al.
        A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women.
        N Engl J Med. 1999; 341: 650-658
        • Donahue R.P.
        • Abbott R.D.
        • Reed D.M.
        • et al.
        Physical activity and coronary heart disease in middle-aged and elderly men: the Honolulu Heart Program.
        Am J Public Health. 1988; 78: 683-685
        • Hakim A.A.
        • Curb J.D.
        • Petrovitch H.
        • et al.
        Effects of walking on coronary heart disease in elderly men: the Honolulu Heart Program.
        Circulation. 1999; 100: 9-13
        • Smith Jr., S.C.
        • Allen J.
        • Blair S.N.
        • et al.
        AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the national heart, lung, and blood institute.
        J Am Coll Cardiol. 2006; 47: 2130-2139
        • Suaya J.A.
        • Shepard D.S.
        • Normand S.-L.T.
        • et al.
        Use of cardiac rehabilitation by medicare beneficiaries after myocardial infarction or coronary bypass surgery.
        Circulation. 2007; 116: 1653-1662
        • Thomas S.
        • Rich M.W.
        Epidemiology, pathophysiology, and prognosis of heart failure in the elderly.
        Heart Fail Clin. 2007; 3: 381-387
        • Kitzman D.W.
        • Gardin J.M.
        • Gottdiener J.S.
        • et al.
        Importance of heart failure with preserved systolic function in patients ≥ 65 years of age.
        Am J Cardiol. 2001; 87: 413-419
        • Kitzman D.W.
        • Daniel K.R.
        Diastolic heart failure in the elderly.
        Heart Fail Clin. 2007; 3: 437-453
        • Kenchaiah S.
        • Sesso H.D.
        • Gaziano J.M.
        Body mass index and vigorous physical activity and the risk of heart failure among men.
        Circulation. 2009; 119: 44-52
        • O'Connor C.M.
        • Whellan D.J.
        • Lee K.L.
        • et al.
        Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.
        JAMA. 2009; 301: 1439-1450
        • Duscha B.D.
        • Schulze P.C.
        • Robbins J.L.
        • et al.
        Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training.
        Heart Fail Rev. 2008; 13: 21-37
        • Witham M.D.
        • Struthers A.D.
        • McMurdo M.E.
        Exercise training as a therapy for chronic heart failure: can older people benefit?.
        J Am Geriatr Soc. 2003; 51: 699-709
        • Fiatarone M.
        • O'Neill E.
        • Ryan N.
        • et al.
        Exercise training and nutritional supplementation for physical frailty in very elderly people.
        N Engl J Med. 1994; 330: 1769-1775
        • Trappe S.
        • Williamson D.
        • Godard M.
        Maintenance of whole muscle strength and size following resistance training in older men.
        J Gerontol A Biol Sci Med Sci. 2002; 57: B138-B143
        • Binder E.F.
        • Yarasheski K.E.
        • Steger-May K.
        • et al.
        Effects of progressive resistance training on body composition in frail older adults: results of a randomized, controlled trial.
        J Gerontol A Biol Sci Med Sci. 2005; 60: 1425-1431
        • Nordström A.
        • Karlsson C.
        • Nyquist F.
        • et al.
        Bone loss and fracture risk after reduced physical activity.
        J Bone Miner Res. 2005; 20: 202-207
        • Ringsberg K.A.
        • Gärdsell P.
        • Johnell O.
        • et al.
        The impact of long-term moderate physical activity on functional performance, bone mineral density and fracture incidence in elderly women.
        Gerontology. 2001; 47: 15-20
        • Vogel T.
        • Brechat P.H.
        • Lepretre P.M.
        • et al.
        Health benefits of physical activity in older patients: a review.
        Int J Clin Pract. 2009; 63: 303-320
        • Kohrt W.M.
        • Bloomfield S.A.
        • Little K.D.
        • et al.
        American College of Sports Medicine Position Stand: physical activity and bone health.
        Med Sci Sports Exerc. 2004; 36: 1985-1996
        • Campbell A.J.
        • Borrie M.J.
        • Spears G.F.
        Risk factors for falls in a community-based prospective study of people 70 years and older.
        J Gerontol A Biol Sci Med Sci. 1989; 44: M112-M117
        • Nevitt M.C.
        • Cummings S.R.
        • Hudes E.S.
        Risk factors for injurious falls: a prospective study.
        J Gerontol A Biol Sci Med Sci. 1991; 46: M164-M170
        • Tinetti M.E.
        Preventing falls in elderly persons.
        N Engl J Med. 2003; 348: 42-49
        • Chang J.T.
        • Morton S.C.
        • Rubenstein L.Z.
        • et al.
        Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials.
        BMJ. 2004; 328: 680
        • Sherrington C.
        • Lord S.R.
        • Finch C.F.
        Physical activity interventions to prevent falls among older people: update of the evidence.
        J Sci Med Sport. 2004; 7: 43-51
        • Baker M.K.
        • Atlantis E.
        • Fiatarone Singh M.A.
        Multi-modal exercise programs for older adults.
        Age Ageing. 2007; 36: 375-381
        • Robertson M.C.
        • Campbell A.J.
        • Gardner M.M.
        • et al.
        Preventing injuries in older people by preventing falls: a meta-analysis of individual-level data.
        J Am Geriatr Soc. 2002; 50: 905-911
        • Li F.
        • Harmer P.
        • Fisher K.J.
        • et al.
        Tai Chi and fall reductions in older adults: a randomized controlled trial.
        J Gerontol A Biol Sci Med Sci. 2005; 60: 187-194
        • Klein P.J.
        • Adams W.D.
        Comprehensive therapeutic benefits of Taiji: a critical review.
        Am J Phys Med Rehabil. 2004; 83: 735-745
        • Voukelatos A.
        • Cumming R.G.
        • Lord S.R.
        • et al.
        A randomized, controlled trial of tai chi for the prevention of falls: the Central Sydney tai chi trial.
        J Am Geriatr Soc. 2007; 55: 1185-1191
        • Kramer A.F.
        • Erickson K.I.
        • Colcombe S.J.
        Exercise, cognition, and the aging brain.
        J Appl Physiol. 2006; 101: 1237-1242
        • Yaffe K.
        • Barnes D.
        • Nevitt M.
        • et al.
        A prospective study of physical activity and cognitive decline in elderly women: women who walk.
        Arch Intern Med. 2001; 161: 1703-1708
        • Weuve J.
        • Kang J.H.
        • Manson J.E.
        • et al.
        Physical activity, including walking, and cognitive function in older women.
        JAMA. 2004; 292: 1454-1461
        • Hamer M.
        • Chida Y.
        Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence.
        Psychol Med. 2009; 39: 3-11
        • Rovio S.
        • Kåreholt I.
        • Helkala E.-L.
        • et al.
        Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.
        Lancet Neurol. 2005; 4: 705-711
        • Abbott R.D.
        • White L.R.
        • Ross G.W.
        • et al.
        Walking and dementia in physically capable elderly men.
        JAMA. 2004; 292: 1447-1453
        • Lautenschlager N.T.
        • Cox K.L.
        • Flicker L.
        • et al.
        Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.
        JAMA. 2008; 300: 1027-1037
        • Heckman G.A.
        • McKelvie R.S.
        Cardiovascular aging and exercise in healthy older adults.
        Clin J Sport Med. 2008; 18: 479-485
        • Churchill J.D.
        • Galvez R.
        • Colcombe S.
        • et al.
        Exercise, experience and the aging brain.
        Neurobiol Aging. 2002; 23: 941-955
        • Cotman C.W.
        • Berchtold N.C.
        Exercise: a behavioral intervention to enhance brain health and plasticity.
        Trends Neurosci. 2002; 25: 295-301
        • van Praag H.
        • Shubert T.
        • Zhao C.
        • et al.
        Exercise enhances learning and hippocampal neurogenesis in aged mice.
        J Neurosci. 2005; 25: 8680-8685
        • Lopez-Lopez C.
        • LeRoith D.
        • Torres-Aleman I.
        Insulin-like growth factor I is required for vessel remodeling in the adult brain.
        Proc Natl Acad Sci USA. 2004; 101: 9833-9838
        • Jonker J.T.
        • De Laet C.
        • Franco O.H.
        • et al.
        Physical activity and life expectancy with and without diabetes: life table analysis of the Framingham heart study.
        Diabetes Care. 2006; 29: 38-43
        • Wannamethee S.G.
        • Shaper A.G.
        • Walker M.
        Physical activity and mortality in older men with diagnosed coronary heart disease.
        Circulation. 2000; 102: 1358-1363
        • Landi F.
        • Cesari M.
        • Onder G.
        • et al.
        Physical activity and mortality in frail, community-living elderly patients.
        J Gerontol A Biol Sci Med Sci. 2004; 59: 833-837
        • Fried L.P.
        • Kronmal R.A.
        • Newman A.B.
        • et al.
        Risk factors for 5-year mortality in older adults: the cardiovascular health study.
        JAMA. 1998; 279: 585-592
        • Sundquist K.
        • Qvist J.
        • Sundquist J.
        • et al.
        Frequent and occasional physical activity in the elderly: a 12-year follow-up study of mortality.
        Am J Prev Med. 2004; 27: 22-27
        • Hakim A.A.
        • Petrovitch H.
        • Burchfiel C.M.
        • et al.
        Effects of walking on mortality among nonsmoking retired men.
        N Engl J Med. 1998; 338: 94-99
        • Knoops K.T.
        • de Groot L.C.
        • Kromhout D.
        • et al.
        Mediterranean diet, lifestyle factors, and 10-year mortality in elderly european men and women: the HALE project.
        JAMA. 2004; 292: 1433-1439
        • Pressman S.D.
        • Cohen S.
        Does positive affect influence health?.
        Psychol Bull. 2005; 131: 925-971
        • Wolin K.Y.
        • Glynn R.J.
        • Colditz G.A.
        • et al.
        Long-term physical activity patterns and health-related quality of life in U.S. women.
        Am J Prev Med. 2007; 32: 490-499
        • Kruger J.
        • Bowles H.R.
        • Jones D.A.
        • et al.
        Health-related quality of life, BMI and physical activity among US adults (ges18 years): national physical activity and weight loss survey, 2002.
        Int J Obes. 2006; 31: 321-327
        • Shih M.
        • Hootman J.M.
        • Kruger J.
        • et al.
        Physical activity in men and women with arthritis: national health interview survey, 2002.
        Am J Prev Med. 2006; 30: 385-393
        • Rejeski W.J.
        • Mihalko S.L.
        Physical activity and quality of life in older adults.
        J Gerontol A Biol Sci Med Sci. 2001; 56: 23-35
        • Drewnowski A.
        • Evans W.J.
        Nutrition, physical activity, and quality of life in older adults: summary.
        J Gerontol A Biol Sci Med Sci. 2001; 56: 89-94
        • Brown D.W.
        • Balluz L.S.
        • Heath G.W.
        • et al.
        Associations between recommended levels of physical activity and health-related quality of life Findings from the 2001 Behavioral Risk Factor Surveillance System (BRFSS) survey.
        Prev Med. 2003; 37: 520-528
        • Penedo F.J.
        • Dahn J.R.
        Exercise and well-being: a review of mental and physical health benefits associated with physical activity.
        Curr Opin Psychiatry. 2005; 18: 189-193
        • Bazargan M.
        Self-reported sleep disturbance among African-American elderly: the effects of depression, health status, exercise, and social support.
        Int J Aging Hum Dev. 1996; 42: 143-160
        • Morgan K.
        Daytime activity and risk factors for late-life insomnia.
        J Sleep Res. 2003; 12: 231-238
        • Ohayon M.M.
        Interactions between sleep normative data and sociocultural characteristics in the elderly.
        J Psychosom Res. 2004; 56: 479-486
        • King A.C.
        • Oman R.F.
        • Brassington G.S.
        • et al.
        Moderate-intensity exercise and self-rated quality of sleep in older adults. A randomized controlled trial.
        JAMA. 1997; 277: 32-37
        • Singh N.A.
        • Clements K.M.
        • Fiatarone M.A.
        A randomized controlled trial of the effect of exercise on sleep.
        Sleep. 1997; 20: 95-101
        • Mazzeo R.S.
        • Cavanagh P.
        • Evans W.J.
        • et al.
        Exercise and physical activity for older adults: ACSM position statement.
        Med Sci Sports Exerc. 1998; 30: 992-1008
        • Nelson M.E.
        • Rejeski W.J.
        • Blair S.N.
        • et al.
        Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association.
        Med Sci Sports Exerc. 2007; 39: 1435-1445
        • Wisloff U.
        • Stoylen A.
        • Loennechen J.P.
        • et al.
        Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study.
        Circulation. 2007; 115: 3086-3094
        • Vogiatzis I.
        • Terzis G.
        • Nanas S.
        • et al.
        Skeletal muscle adaptations to interval training in patients with advanced COPD∗.
        Chest. 2005; 128: 3838-3845
        • Broman G.
        • Quintana M.
        • Lindberg T.
        • et al.
        High intensity deep water training can improve aerobic power in elderly women.
        Eur J Appl Physiol. 2006; 98: 117-123
        • Cancela Carral J.M.
        • Ayán Pérez C.
        Effects of high-intensity combined training on women over 65.
        Gerontology. 2007; 53: 340-346
        • Cress E.M.
        • Buchner D.M.
        • Prohaska T.
        • et al.
        Physical activity programs and behavior counseling in older adult populations.
        Med Sci Sports Exerc. 2004; 36: 1997-2003
        • Oka R.
        • King A.
        Sources of social support as predictors of exercise adherence in women and men age 50 to 65 years.
        Womens Health. 1995; 1: 161-175
        • Petrella P.J.
        • Koval J.J.
        • Cunningham D.A.
        • et al.
        Can primary care doctors prescribe exercise to improve fitness?.
        Am J Prev Med. 2003; 24: 316-322
        • Dauenhauer J.A.
        • Podgorski C.A.
        • Karuza J.
        Prescribing exercise for older adults: a needs assessment comparing primary care physician, nurse practitioners, and physician assistants.
        Gerontol Geriatr Educ. 2006; 26: 81-99
        • Andersen R.E.
        • Blair S.N.
        • Cheskin L.J.
        • et al.
        Encouraging patients to become more physically active: the physician's role.
        Ann Intern Med. 1997; 127: 395-400
        • Dunstan D.W.
        • Daly R.M.
        • Owen N.
        • et al.
        Home-based resistance training in not sufficient to maintain improved glycemic control following supervised training in older individuals with type 2 diabetes.
        Diabetes Care. 2005; 28: 3-9
        • Nelson M.
        • Layne J.
        • Bernstein M.
        • et al.
        The effects of multidimensional home-based exercise on functional performance in elderly people.
        J Gerontol A Biol Sci Med Sci. 2004; 59: 154-160
        • Ransdell L.
        • Taylor A.
        • Oakland D.
        • et al.
        Daughters and mothers exercising together: effects of home- and community-based programs.
        Med Sci Sports Exerc. 2003; 35: 286-296
        • Ravaud P.
        • Giraudeau B.
        • Logeart I.
        • et al.
        Management of osteoarthritis (OA) with an unsupervised home based exercise programme and/or patient administered assessment tools. A cluster randomised controlled trial with a 2x2 factorial design.
        Ann Rheum Dis. 2004; 63: 703-708
        • Daub W.D.
        • Knapik G.P.
        • Black W.R.
        Strength training early after myocardial infarction.
        J Cardiopulm Rehabil. 1996; 16: 100-109
        • Belardinelli R.
        • Lacalaprice F.
        • Ventrella C.
        • et al.
        Waltz dancing in patients with chronic heart failure: new form of exercise training.
        Circ Heart Fail. 2008; 1: 107-114